Salvia divinorum increases alcohol intake and tonic immobility whilst decreasing food intake in Wistar rats

The kappa-opioid system (KOP) is the key in drug abuse. Of all compounds isolated from Salvia divinorum (S. divinorum), salvinorin-A (Sal-A) predominant. Further, Sal-A only compound within S. which reported to have psychoactive properties as a powerful receptor (KOPr) agonist. Based on role of KOP consumption drugs, extract (SDE) and may modify alcohol intake Wistar rats. Assessing voluntary consummatory behavior, food natural reward behavior tonic immobility indicative anxiety-like present study sought identify both SDE rat model. Forty-eight adult male rats were randomly divided into six groups: control, naive vehicle, alcohol-naive SDE, Sal-A, alcohol-consumption Sal-A. Alcohol assessed for two weeks. In middle these weeks, (containing ~1 mg/kg Sal-A) or was injected intraperitoneally once day week. Tonic testing performed once. administration produced significant increase especially with history forced juvenile age, elicited an animals without previous exposure, prolonged duration decreased intake. conclusion, stimulated independent exposure respectively, also anorexigenic effect, increased anxious-like behavior.